https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3794 Wed 11 Apr 2018 15:59:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1306 50%) compared with controls for each mutant. mIPSC decay times were unchanged in spa/spa (4.5 ± 0.3 vs 4.7 ± 0.2 ms), reduced in spd/spd (2.7 ± 0.2 vs 4.7 ± 0.2 ms), and increased in ot/ot (12.3 ± 1.2 vs 4.8 ± 0.2 ms). Thus, in spastic, GlyRs are functionally normal but reduced in number, whereas in spasmodic, GlyR kinetics is faster. The oscillator mutation results in complete absence of α1-containing GlyRs; however, some non-α1-containing GlyRs persist at synapses. Fluctuation analysis of membrane current, induced by glycine application to outside-out patches, showed that mean single-channel conductance was increased in spa/spa (64.2 ± 4.9 vs 36.1 ± 1.4 pS), but unchanged in spd/spd (32.4 ± 2.1 vs 35.3 ± 2.1 pS). GlyR-mediated whole-cell currents in spa/spa exhibited increased picrotoxin sensitivity (27 vs 71% block for 100 µM), indicating α1 homomeric GlyR expression. The picrotoxin sensitivity of evoked glycinergic IPSCs and conductance of synaptic GlyRs, as determined by nonstationary variance analysis, were identical for spa/spa and controls. Together, these findings show the three mutations disrupt GlyR-mediated inhibition via different physiological mechanisms, and the spastic mutation results in "compensatory" α1 homomeric GlyRs at extrasynaptic loci.]]> Wed 11 Apr 2018 14:28:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6899 Wed 11 Apr 2018 10:30:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3792 Wed 11 Apr 2018 09:24:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38654 Wed 06 Dec 2023 09:52:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50234 Tue 19 Sep 2023 15:13:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40857 Tue 19 Jul 2022 13:42:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47074 Tue 13 Dec 2022 16:21:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47039 Tue 13 Dec 2022 14:15:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7759 Sat 24 Mar 2018 08:41:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1388 Sat 24 Mar 2018 08:28:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11009 Sat 24 Mar 2018 08:07:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17416 Sat 24 Mar 2018 08:01:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30898 Scaevola albida, Chrysocephalum semipapposum, and Enteropogon acicularis. Some Australian native plants inhibited nitrification in their rhizosphere. We propose future studies on these selected plant species by identifying and characterising the nitrification inhibiting compounds and also the potential of nitrification inhibition in reducing nitrogen losses through nitrate leaching and nitrous oxide emission.]]> Sat 24 Mar 2018 07:30:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3327 Sat 24 Mar 2018 07:23:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3791 Go effect was found, consistent with previous work linking this component with inhibitory processing. In control children this effect was particularly strong in the right frontal region, while children with AD/HD showed a much larger NoGo>Go effect, and an earlier N2 peak, than controls, with a focal shift to the left frontal region. Conclusions: Compared with normal controls, children with AD/HD demonstrate early stimulus processing atypicalities, suggesting problems with sensory registration and identification of stimuli. Further, N2 results suggest that children with AD/HD must trigger the inhibition process earlier and more strongly than controls to perform at a comparable behavioural level. Significance: The results support the theory that behavioural inhibition is deficient in AD/HD, as children with AD/HD show abnormalities in inhibitory ERP components relating to the effort involved in inhibiting a prepotent response.]]> Sat 24 Mar 2018 07:18:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45891 Mon 07 Nov 2022 16:30:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35747 Fri 15 Nov 2019 11:00:30 AEDT ]]>